Our approach to analyzing the data from electronic health records and then forming the regression models to develop qSOFA, we developed by using the data from the record. With any vital sign that’s recorded by nurses or clinicians at the bedside, there may be some that are more accurate than others. What effect do you think this has on the qSOFA data, if any? One of the qSOFA parameters is respiratory rate, which, as a vital sign, is somewhat notorious for being measured and documented inaccurately. And this was what prompted the task force to get together and come up with more simple criteria to help clinicians with this task. And patients can manifest that organ dysfunction in a variety of ways, whether it’s altered mental status, or difficulty breathing, or low blood pressure, or all of these together, and as a result, clinicians may encounter a patient with sepsis, but vary in both how fast they recognize this, and in whether they even call them septic or not. Sepsis is a combination of suspected infection, that is causally related to life-threatening organ dysfunction. Sepsis is a common and deadly syndrome, but there isn’t one checkbox or patient symptom that identifies them as having sepsis or not. Why do you think it’s so hard to nail down a definition and criteria for sepsis?
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